Cutting Edge: CD83 Regulates the Development of Cellular Immunity

Cutting edge: CD83 regulates the development of cellular immunity.

We recently found that human CD83, a marker of mature dendritic cells, is an adhesion receptor that binds to resting monocytes and a subset of activated CD8(+) T cells. We injected CD83-Ig into mice transplanted with the immunogenic P815 mastocytoma and showed that it significantly enhanced the rate of tumor growth and inhibited the development of cytotoxic T cells. In contrast, mice immunized ...

Cutting Edge: Vitamin D Regulates Lipid

Vitamin D has long been linked to resistance to tuberculosis , an infectious respiratory disease that is increasingly hard to treat because of multidrug resistance. Previous work established that vitamin D induces mac-rophage antimicrobial functions against Mycobacte-rium tuberculosis. In this article, we report a novel, metabolic role for vitamin D in tuberculosis identified through integrated...

Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells.

Regulatory T cells (Tregs) have a reduced capacity to activate the PI3K/Akt pathway downstream of the TCR, and the resulting low activity of Akt is necessary for their development and function. The molecular basis for the failure of Tregs to activate Akt efficiently, however, remains unknown. We show that PH-domain leucine-rich-repeat protein phosphatase (PHLPP), which dephosphorylates Akt, is ...

the impact of morphological awareness on the vocabulary development of the iranian efl students

this study investigated the impact of explicit instruction of morphemic analysis and synthesis on the vocabulary development of the students. the participants were 90 junior high school students divided into two experimental groups and one control group. morphological awareness techniques (analysis/synthesis) and conventional techniques were used to teach vocabulary in the experimental groups a...

Special Issue: Cutting-Edge Research on Intestinal Immunity and Inflammation